Pentobarbital-anesthetized and instrumented dogs (n = 8) were maintained and observed for 60 minutes or until death. Methods: This nonblind interventional study was performed in an established canine model of verapamil toxicity, without concurrent control animals. Ask your doctor for further details and instructions before taking any medications. Atorvastatine, simvastatine), ciclosporine, sirolimus, tacrolimus en doxorubicine), die van digoxine met 50–70% verapamil antidote (zelfs. Atrial Fibrillation / drug therapy Binding, Competitive / drug effects Calcium Chloride / therapeutic use* Humans Hypotension / chemically induced Hypotension / drug therapy* Male Verapamil / adverse effects* Verapamil / antagonists & inhibitors Substances Verapamil Calcium Chloride. The animals were overdosed with verapamil, 15 mg/ kg IV, over 30 minutes Verapamil kan de plasmaconcentratie van geneesmiddelen die substraat zijn voor CYP1A, CYP2C, CYP3A4 en/of voor Pgp verhogen (bv. Yes, it is common for doctors to prescribe Hydrochlorothiazide with Verapamil. Verapamil is used to treat hypertension ( high blood pressure ), angina (chest pain), and certain heart rhythm disorders. MeSH terms Animals Antidotes / therapeutic use*. All controls died within 85 min. All treatments tended to improve hemodynamics; verapamil antidote however, glucotrol dosage forms HIE significantly improved maximum elastance at end systole, left ventricular end diastolic pressure and coronary artery blood flow vs. Verapamil injection verapamil antidote is used to rapidly or temporarily restore normal heartbeats in people with certain heart rhythm disorders. Verapamil decreased all hemodynamic parameters during titration. Buspiron, almotriptan, glibenclamide, propranolol, metoprolol, midazolam, imipramine, theofylline, kinidine, carbamazepine, sommige statinen (bv. In conclusion, calcium as well as sympathomimetic amines are potent antidotes against the cardiovascular toxicity of verapamil, the latter being superior to calcium in their ability to improve pacemaker activity and AV-conduction.