Issue 32/33. January – June 2002
Substance |
Enalapril |
|---|---|
Brand name: |
Vasotec |
Description |
|
Ace inhibitor |
|
In patients with chronic heart failure, vasotec increases exercise tolerance and reduce the severity of heart failure |
|
Brands: |
Vasotec |
Availability: |
Prescription needed |
Pregnancy: |
Consult a doctor |
Alcohol: |
We strongly recommend abstaining from alcohol |
Side Effects: |
Blurred vision |
Interactions: |
Lasix (furosemide) |
43 Note: If patients are concomitantly receiving diuretic therapy, begin with 0. Vasotec is also used to treat congestive heart failure in adults. Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. If not concurrently receiving diuretics, initiate enalapril 5 mg PO qDay; if concurrently receiving diuretics and responding to 0. Decreases plasma angiotensin II, increases plasma renin activity, decreases aldosterone secretion Abstract. These drugs are used in the treatment of hypertension and congestive heart failure NCBI Bookshelf. The angiotensin-converting enzyme (ACE) inhibitors available today include captopril (Capoten), enalapril (Vasotec), enaloprilat (Vasotec IV), lisinopril (Prinivil, Zestril), benazepril (Lotensin), fosinopril (Monopril), and ramipril (Atace). Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. When pregnancy is detected, discontinue VASOTEC ® as soon as possible. The initial dosage of enalapril is 5 mg once daily ( Table 49. Its empirical formula is C 18 H 24 N 2 O 5 ·2H 2 O and its structural formula is:. Enalapril maleate is a nonsulfhydryl prodrug of the long-acting ACE inhibitor enalaprilat. Enalaprilat injection is used to treat high blood pressure (hypertension). If it continues for a long time, the heart and arteries may not function properly VASOTEC ® (ENALAPRIL MALEATE) Rx Only. 5 mg PO twice daily, initially. 25 mg at 6-hour intervals thereafter; if adequate, administer 0. In this study there was no evidence of a blunting of the antihypertensive action of VASOTEC (see. Enalapril maleate (Vasotec®) 5 mg daily. These drugs are used in the treatment of hypertension and congestive heart failure Enalaprilat is an angiotensin converting enzyme inhibitor. ) If after one hour there is an inadequate. Maximum Daily Dose (mg) Captopril (Capoten®) 12. [3] It is given by mouth or by injection into a vein. Has been studied with only one other antihypertensive agent, furosemide, which showed approximately additive effects on blood pressure VASOTEC * I. High blood pressure adds to the workload of the heart and arteries. It is chemically described as ( S )-1- [ N - (1-carboxy-3-phenylpropyl)-L-alanyl]-L-proline dihydrate. 18,25 The oral preparations are available in tablets of 2. Drug information provided by: IBM Micromedex US Brand Name Vasotec IV Descriptions Enalaprilat injection is used to treat high blood pressure (hypertension). Enalaprilat is an angiotensin converting enzyme inhibitor. As with all medications, there are possible side effects you may experience while taking Vasotec. Conversion from IV enalaprilat to oral enalapril therapy: If not concurrently. Its molecular formula is C 18 H 24 N 2 O 5 • 2H 2 O and its structural formula is: Enalaprilat is a white to off-white, crystalline powder with a molecular weight of 384. , D5W) or saline solution (NS) usually every 6 hours; or as directed by your doctor. Is indicated for the treatment of hypertension when oral therapy is not practical. 625 mg IV over 5 minutes; if the effect is not adequate after 1 hour, repeat the dose and administer 1. See full prescribing information for complete boxed warning. [2] For heart failure, it is generally used with a diuretic, such as furosemide. Vasotec is also used to treat a disorder of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart) VASOTEC is indicated for the treatment of symptomatic heart failure, usually in combination with diuretics and digitalis. HOW TO USE: Inject this medication directly into a vein (IV) over 5 minutes or give IV over at least 5 minutes mixed in a dextrose- containing (e. When given together with thiazide-type diuretics, the blood pressure lowering effects of VASOTEC are approximately additive. The usual daily dose is 10 to 40 mg, singly or in divided doses Mechanism of Action: This ACE inhibitor suppresses the renin-angiotensin-aldosterone system, and prevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor; may inhibit angiotensin II at local vascular, renal sites. In a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving VASOTEC. For patients with creatinine clearance ≤30 mL/min (serum creatinine ≥3 mg/dL), the initial dose is 0. 5 mg PO qDay; titrate upwards as necessary. The recommended initial dose is 2. (Enalaprilat) is a sterile aqueous solution for intravenous administration. The dosage is based on your medical condition and response to therapy 2. Increase the dose as tolerated over a few days or weeks up to 10 to 20 mg PO twice daily. 25-5 mg q6hr; avoid IV administration in unstable heart failure or acute myocardial infarction. Guidelines recommend an angiotensin-converting enzyme (ACE) inhibitor in combination with an evidence-based beta blocker and aldosterone antagonist, in select patients, for patients with chronic reduced ejection fraction heart failure (HFrEF) NYHA class I to IV to reduce. Note: If patients are concomitantly receiving diuretic therapy, begin with 0. Common and less severe side effects include: 3 Cough Dizziness Rash Weakness Hypotension Abdominal pain Syncope Diarrhea Urinary tract infection Headache Rash Nausea Vertigo Fatigue Pallor Increased thirst Loss of appetite Insomnia Easy bruising. 9% Sodium Chloride injection) Indication: Treatment of hypovolemia when plasma volume expansion. Conversion from IV to oral dosage form. If it continues for a long time, the heart and arteries may not function properly Vasotec is used to treat high blood pressure (hypertension) in adults and children who are at least 1 month old. In the placebo-controlled studies that demonstrated improved survival, patients were titrated as tolerated up to 40 mg, administered in two divided doses. Product name: HESPAN® (6% Hetastarch in 0. Pharmacologic Class: ACE Inhibitor Uses for Vasotec I. 25 mg of enalaprilat every six hours is recommended for patients with a creatinine clearance >30 mL/min (serum creatinine of up to approximately 3 mg/dL). NDA Number: BN890105 Manufacturer: B.
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